Susan and Mike decide to move in together, much to Edie's displeasure. Meanwhile, Lynette takes steps to make sure Annabel doesn't come between her and Tom. Also, Bree comes to a realization about her "buddy" George the pharmacist who continues to interfere in her and Rex's lives. Carlos' legal problems take a turn for the worse, when Gabrielle decides to leave him. Mrs. Huber's journal reveals some secrets. Lastly, two new faces arrive on Wisteria Lane.

Bill joins the military group formed by Ethan, Dominic and Michael. The three men hold a young alien hostage, Isla. Catherine, Sophia and Nathan continue to search for Bill. Adina, and the aliens also set out to find Bill. Chloe accuses the blow when she realizes that Sacha killed Ash. She suggests to her increasingly unstable son to run away with her.

At the university, Sophia watches the videos recorded by Dylan, a young man they found dead, while Catherine focuses on the algorithms he left behind and which decipher the behavior of robots. Thanks to Bill's intervention, Isla manages to flee and join her family.

Korvo tries to get the family involved in repairing the spaceship, but they attend a birthday party instead, where he is inspired to become a magician. Using his computer system Aisha, Korvo creates a technologically advanced magic act; he goes viral and prepares for a Las Vegas show, which will culminate in him leaping through a black hole. Korvo ignores his family's warning that jealous magicians plan to kill him; the family save him from being shot, but he dies when the black hole trick goes awry. The grieving family agree to repair the ship in Korvo's memory, and he reappears, having faked his death to bring them closer together. Yumyulack adds a woman named Cherie to his shrunken collection.

Blimey! The Solar Opposites have repaired their ship and are heading to space, unless something goes hilariously wrong...

As the dust settles on their brave new world, the survivors are forced to face some cold truths. Catherine is stunned to discover the part she played in bringing about the alien attack. Helen becomes fixated on revenge. And Emily momentarily regains her sight. But is the miracle cause for celebration, or concern?

The survivors make some disarming discoveries not only about the aliens but also about themselves. Mokrani goes on the offensive, taking the fight to the aliens. Ash is forced to make the hardest decision of his life. And Chloe’s past catches up with her, threatening to rip apart the delicate semblance of normality she is so desperately clinging on to.

Cracks start to show as the survivors find different ways to cope. Jonathan’s increasingly perturbed by Sacha’s strange behaviour. Emily proves to be an exciting conundrum for Bill. And Mokrani is horrified as his men delight in the opportunity to exact revenge.

When Nic finds herself under investigation in Lily's death, Conrad comes to her defense, but ends up making the situation worse. During a routine surgery, Bell's patient accidentally catches fire, leaving the hospital to start an immediate investigation into his medical records.

Conrad and Devon work tirelessly to save the life of Bradley, a fellow doctor who has fallen through the hospital skylight. As the team contemplates how and why he fell through in the first place, Dr. Bell looks back to when he benched Bradley for falling asleep during surgery. Amidst the madness, Mina is tasked with showing Chastain’s new star cardiothoracic surgeon, Dr. AJ Austin, around the hospital, but is caught off-guard by his volatile personality. Meanwhile, Nic finds renewed enthusiasm when she uncovers an oncologist who used to work with Lane, but while paying him a visit, she fears that she’s being followed.

Devon and Conrad race against the clock to save the life of a woman who is deteriorating fast from undetermined symptoms. When the patient turns out to be a hero who helps previous criminals get their lives back together, the team relies on her family of ex-cons to help diagnose and treat her. Tensions rise as Nic continues her search for evidence to incriminate Lane, but must simultaneously tend to her sister, Jessie, who is rushed into the ER. Meanwhile, York returns to the hospital with his mother, who is in need of a risky procedure, and comes face-to-face with the stone-cold Dr. AJ Austin.

Richard ponders his surgical abilities. Jo is charmed by her patient's brother; Megan makes sure Teddy and Owen talk out their differences. A pet python causes an uproar.

Tensions at Grey Sloan Memorial rise as the effects of the physician shortage begin to show. Meredith struggles to step away from work as she spends a sick day at home with Zola. The hospital receives an unexpected visitor.

Bailey is on edge when an accreditation council reviews the residency program; Nick returns to Seattle to perform a first-of-its-kind operation with Meredith.

When Vic helps her parents through a devastating loss, they have a long overdue conversation about the anguish of being Black in America.

Maya addresses some unresolved family issues, and the crew takes matters into their own hands when faced with a life-or-death moment on scene. Meanwhile, Andy and Sullivan's marriage is put to the test.

When Lynette's father-in-law pays a visit to to the family, she unwittingly learns a family secret. Meanwhile, Susan is disturbed by Julie's growing romance with Zach. Rex attempts to reconcile with Bree as she tries to play hard-to-get. Lastly, Gabrielle is shocked when John's parents ask her for a favor in convincing John to move back home as he officially turned eighteen and no longer wants to live at home and trying to pursue a relationship with Gabrielle.

It's Valentine's Day on Wisteria Lane, and love is all around (sort of), as Susan looks forward to a romantic date with Mike, until she learns a surprising fact about her favorite plumber. Meanwhile, after reconciling their relationship, Bree discovers something new about her husband Rex when it comes to his sexual needs. Lynette's neighbor accuses the Scavo twins of thievery as Lynette tries her best to handle the situation. Lastly, Gabrielle's work adventures continue as she gets a gig as a mattress model.

Mike Delfino is questioned about Mrs. Huber's murder by police and is arrested. John's friend, Justin attempts to blackmail Gabrielle with his knowledge of their affair. Meanwhile, Tom wants a big promotion, but Lynette fears that she'd be home alone with the kids more than ever and tries her best in discouraging him in taking the job. Also, Bree is shocked when she finds a condom. Zach Young plans a pool party for the teens on Wisteria Lane, and things get out of hand. Finally, someone comes out of the closet.

When a magazine editor is discovered dead in her Chestnut Hill mansion, Megan must once again slip back into the high society group she used to be a part of. In order to confront a prime suspect, Megan attends one of her mother's social events.

When Melinda goes to visit friends who are experiencing problems with their house, she finds the ghost of six-year-old little girl who drowned. Melinda then tries to help the family of the little girl.

Mayhem ensues on The Odyssey when high-profile book tours for tradwives and sex-positive groups are double-booked; Max, Avery and Tristan provide medical attention to both VIP authors.

Megan is surprised to discover she has a connection to a woman found dead in a hotel room; Megan starts taking an interest in what is going on around her.

Megan and her team must piece a victim back together when body parts turn up in a back alley. Lacey gets Megan's reluctant permission to film her at work for her school video essay project which in turn has a profound effect on Lacey's view of her mother.

The mysterious death of a beautiful woman keeps Ethan and Curtis guessing. Curtis begins to question Ethan's motives after he becomes fixated on the dead woman's twin sister.

Susan's mom pays an unannounced visit to Wisteria Lane after she and her boyfriend call it quits. Meanwhile, Gabrielle faces Carlos' wrath after he learns about the hospital settlement and tries to change their prenuptial agreement in order to keep Gabrielle in check while he serves his jail sentence. Lynette and Bree experience a chill in their friendship after Bree babysits Lynette's kids and dares to discipline Porter. Also, Bree and Rex visit Andrew at the teen rehab camp where they learn some shocking news about their son. Lastly, Felicia gets closer to Zach and reveals some disturbing details about his family in the past.

Lynette learns that no good deed goes unpunished when she momentarily befriends the mean Mrs. McClusky. Susan's mother decides to try and jump start her and her daughter's love lives. Andrew talks to a priest about his feelings, and tells him of his shocking plans for his mother, Bree. Gabrielle has her credit card declined in an upscale restaurant, and Carlos sends Gabrielle a big message about what will happen if she leaves him.

Gabrielle plans a big party to bid farewell to Carlos, who is about to head off to jail for eight months. Meanwhile George Williams resurfaces in Bree's life, much to Rex's displeasure. Also, Lynette is shocked to learn that Tom's old girlfriend Annabel Foster who he dumped for Lynette has been hired at his firm again. Meanwhile, Zach continues to stalk Julie while Mike tries to separate Susan from Mary Alice's past secrets. Lastly, housewife Gabrielle is suspecting that she's pregnant.

Megan is surprised to discover she has a connection to a woman found dead in a hotel room; Megan starts taking an interest in what is going on around her.

Megan and her team must piece a victim back together when body parts turn up in a back alley. Lacey gets Megan's reluctant permission to film her at work for her school video essay project which in turn has a profound effect on Lacey's view of her mother.

Meredith and Catherine continue to disagree, and Meredith confides in Bailey for support; Richard, Winston and Lucas spend the day outside of the hospital; Blue deals with a relationship from his past; Levi meets the new hospital chaplain.

When Nic finds herself under investigation in Lily's death, Conrad comes to her defense, but ends up making the situation worse. During a routine surgery, Bell's patient accidentally catches fire, leaving the hospital to start an immediate investigation into his medical records.

Conrad and Devon work tirelessly to save the life of Bradley, a fellow doctor who has fallen through the hospital skylight. As the team contemplates how and why he fell through in the first place, Dr. Bell looks back to when he benched Bradley for falling asleep during surgery. Amidst the madness, Mina is tasked with showing Chastain’s new star cardiothoracic surgeon, Dr. AJ Austin, around the hospital, but is caught off-guard by his volatile personality. Meanwhile, Nic finds renewed enthusiasm when she uncovers an oncologist who used to work with Lane, but while paying him a visit, she fears that she’s being followed.

Devon and Conrad race against the clock to save the life of a woman who is deteriorating fast from undetermined symptoms. When the patient turns out to be a hero who helps previous criminals get their lives back together, the team relies on her family of ex-cons to help diagnose and treat her. Tensions rise as Nic continues her search for evidence to incriminate Lane, but must simultaneously tend to her sister, Jessie, who is rushed into the ER. Meanwhile, York returns to the hospital with his mother, who is in need of a risky procedure, and comes face-to-face with the stone-cold Dr. AJ Austin.